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Article

The VEGFA and KDR genes are associated with bilateral and multiple chronic Achilles tendon injuries.

Journal of science and medicine in sport - 1 Sept 2026

Brazier Christina D, Mkumbuzi Nonhlanhla S, Laguette Mary-Jessica N, September Alison V, Collins Malcolm

Abstract excerpt

OBJECTIVES: Pain is the primary symptom of Achilles tendinopathy, with neovascularisation implicated in symptom development despite unclear mechanisms. Neovascularisation and pain are regulated by vascular endothelial growth factor A (VEGFA) and its receptor, KDR. Since VEGFA polymorphisms have previously been associated with Achilles tendinopathy, this study aimed to determine whether VEGFA (rs699947 C>A,...

Read the complete abstract on PubMed

Topics

Humans
Vascular Endothelial Growth Factor A
Achilles Tendon

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Vascular Endothelial Growth Factor Receptor-2

Female

Male

Case-Control Studies

Cross-Sectional Studies

Adult

Tendinopathy

Polymorphism, Single Nucleotide

Haplotypes

Middle Aged

Genotype

Genetic Association Studies

Pain Measurement

Genetic Predisposition to Disease

Source

Identifiers

PMID: 42025555
DOI: 10.1016/j.jsams.2026.04.002

Genes

KDR
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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