Article
Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes.
Development (Cambridge, England) - 1 Feb 1999
Xu C, Liguori G, Persico M G, Adamson E D
Abstract excerpt
Cripto-1(Cr1) protein encoded by the tdgf1 gene, is a secreted growth factor that is expressed early in embryonic development and is re-expressed in some tumors of the breast and colon. During embryonic development, Cr1 is expressed in inner cell mass cells and the primitive streak, and later is...
Topics
- Alleles
- Animals
- Biomarkers
- Cell Differentiation
- Chimera
- Culture Techniques
- Epidermal Growth Factor
- Fibroblasts
- Gastrula
- Genotype
- Growth Substances
- Heart
- Homozygote
- Membrane Glycoproteins
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Morphogenesis