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Article

DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2021

Guo Lilong, Beck Tyler, Fulmer Diana, Ramos-Ortiz Sandra, Glover Janiece, Wang Christina, Moore Kelsey, Gensemer Cortney, Morningstar Jordan, Moore Reece, Schott Jean-Jacques, Le Tourneau Thierry, Koren Natalie, Norris Russell A

Abstract excerpt

BACKGROUND: Mitral valve prolapse (MVP) is a common and progressive cardiovascular disease with developmental origins. How developmental errors contribute to disease pathogenesis are not well understood. RESULTS: A multimeric complex was identified that consists of the MVP gene Dzip1, Cby1, and β-catenin. Co-expression during valve development revealed overlap at the basal body of the primary cilia. Biochemical...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33811421
DOI: 10.1002/dvdy.342
PMCID: PMC8518365

Genes

DZIP1
MVP
CBY1
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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