YAC complementation shows a requirement for <i>Wt1</i> in the development of epicardium, adrenal gland and throughout nephrogenesis

Abstract excerpt

The Wilms' Tumour gene WT1 has important functions during development. Knock-out mice were shown to have defects in the urogenital system and to die at embryonic day E13.5, probably due to heart failure. Using a lacZ reporter gene inserted into a YAC construct, we demonstrate that WT1 is expressed in the early proepicardium, the epicardium and the subepicardial mesenchymal cells (SEMC). Lack of WT1 leads to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Renal and related cancers
• Share to Renal cell carcinoma treatment
• Share to Urological Disorders and Treatments