Article
Outside-in signaling by lipopolysaccharide through a tailless integrin.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1997
Ingalls R R, Arnaout M A, Golenbock D T
Abstract excerpt
Ligand binding to integrins activates intracellular signaling pathways that coordinate and regulate a variety of cellular responses. There is evidence to suggest that the cytoplasmic tails play a key role in several of these signaling events. We sought to determine whether the beta2 integrin complement receptor type 3 (CR3; CD11b/CD18), a receptor for LPS, could initiate an intracellular signal in the absence of...
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