Article
Restoration of the mucous phenotype by retinoic acid in retinoid-deficient human bronchial cell cultures: changes in mucin gene expression.
American journal of respiratory cell and molecular biology - 1 Jan 1999
Koo J S, Yoon J H, Gray T, Norford D, Jetten A M, Nettesheim P
Abstract excerpt
Retinoid-deficient cultures of airway epithelial cells undergo squamous differentiation. Treatment of such cultures with retinoic acid (RA) leads to restoration of the mucous phenotype. The purpose of our study was to characterize the cellular and molecular changes following RA treatment of retin...
Topics
- Blotting, Northern
- Bronchi
- Cell Differentiation
- Cell Line
- Cornified Envelope Proline-Rich Proteins
- Dose-Response Relationship, Drug
- Epithelial Cells
- Gene Expression
- Humans
- Immunohistochemistry
- Kinetics
- Membrane Proteins
- Mucins
- Mucous Membrane
- Phenotype
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Time Factors