Article
Retinoic acid provokes metaplasia of epithelium formed in vitro by adult human epidermal keratinocytes.
Differentiation; research in biological diversity - 1 Apr 1995
Asselineau D, Darmon M
Abstract excerpt
A striking effect of retinoids is their ability to alter cell fate during development. The mucous metaplasia produced by treating chick embryo skin in organ culture with retinoic acid is a classical example of this property. It has been impossible so far to demonstrate that retinoids are able to provoke metaplasia of adult keratinocytes grown in vitro, although these agents have been shown to block terminal...
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