Article
Smoke-induced inhalation injury: effects of retinoic acid and antisense oligodeoxynucleotide on stability and differentiated state of the mucociliary epithelium.
Inflammation - 1 Apr 1998
Bhattacharyya S N, Manna B, Smiley R, Ashbaugh P, Coutinho R, Kaufman B
Abstract excerpt
Rabbit tracheal explants, exposed to burning pine wood smoke, were cultured in a chemically defined medium with and without retinoic acid (+/- RA). Exposures of 15-20 minute led to RA-independent degeneration of the mucociliary epithelial sheath. In 10 minute exposures tissue integrity was retain...
Topics
- Animals
- Cell Differentiation
- Culture Techniques
- Epithelium
- Gene Expression
- Metaplasia
- Microscopy, Electron
- Mucins
- Mucous Membrane
- Oligonucleotides, Antisense
- Phenotype
- Rabbits
- Smoke Inhalation Injury
- Trachea
- Tretinoin