Article
Differentiation of respiratory epithelium: the effects of retinoic acid and carcinogens on the expression of mucociliary vs. squamous phenotype.
Inflammation - 1 Apr 1997
Bhattacharyya S N, Manna B, Ashbaugh P, Coutinho R, Kaufman B
Abstract excerpt
Changes in ultrastructural characteristics and mucin gene expression were examined in rat tracheal explants cultured in a synthetic medium +/- retinoic acid (RA), benzo[a]pyrene (B[a]P) and N-methyl-N-nitrosourea (NMNU). In the RA(+) cultures, no changes in either ultrastructural features or muci...
Topics
- Animals
- Benzo(a)pyrene
- Carcinogens
- Carcinoma, Squamous Cell
- Cell Differentiation
- Culture Media
- Culture Techniques
- Epithelium
- Gene Expression
- Lung Neoplasms
- Metaplasia
- Methylnitrosourea
- Mucins
- Phenotype
- RNA, Messenger
- Rats
- Trachea
- Tretinoin