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Effect of Retinoic Acid on Gene Expression in Human Conjunctival Epithelium: Secretory Phospholipase A<sub>2</sub>Mediates Retinoic Acid Induction of MUC16

26 Oct 2005

Abstract excerpt

PURPOSE: How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood. This study sought to identify vitamin A-responsive genes in ocular surface epithelia using gene microarray analysis of cultures of a human conjunctival epithelial (HCjE) cell line grown with all-trans-retinoic acid (RA). The analysis showed that secretory phospholipase A(2) group IIA...

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PMID: 16249480
DOI: 10.1167/iovs.05-0627

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