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Article

Model Systems for Investigating Mucin Gene Expression in Airway Diseases

1 Jan 2000

Abstract excerpt

Overproduction of mucus and of mucin glycoproteins and goblet cell hyperplasia occurs in chronic obstructive airway diseases, including asthma and cystic fibrosis. Mucus overproduction results from alterations in several cellular processes, including altered regulation of airway mucin genes on exposure to environmental and infectious agents and to inflammatory mediators. Seven of the nine identified MUC genes...

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PMID: 11066028
DOI: 10.1089/jam.2000.13.245

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