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Article

TCR diversity in gammadeltaTCR+ hybridomas derived from mice given portal vein donor-specific pre-immunization and skin allografts.

Immunology letters - 1 Dec 1998

Sun Y, Chen Z, Chung S W, Zeng H, Gorczynski R M

Abstract excerpt

Portal venous (p.v.) immunization with multiple minor histoincompatible cells leads to antigen-specific increased skin allograft survival. GammadeltaTCR+ hybridoma cells, prepared from mesenteric lymphocytes of p.v. immunized animals, can adoptively transfer this increased graft survival to naive animals. We have analyzed VgammaVdelta gene usage, and TCR gamma-chain junctional diversity in gammadeltaTCR+...

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PMID: 9870659
DOI: 10.1016/s0165-2478(98)00087-x

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