Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire.

doi:10.1084/jem.172.1.139

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Article

Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire.

The Journal of experimental medicine - 1 Jul 1990

Fink P J, Blair M J, Matis L A, Hedrick S M

Abstract excerpt

Immunization of both B10.A and B10.S(9R) mice with pigeon cytochrome c (pcc) elicits T cells capable of proliferating to pcc presented on I-E major histocompatibility complex (MHC) molecules. The T cell receptor (TCR) repertoire used by pcc-specific T cells from these two strains is markedly different, even for T cells recognizing very similar antigen/MHC complexes. Our current studies have been directed toward...

Topics

Animals
Antigen-Presenting Cells
Blotting, Southern
Cell Line
Chimera
Columbidae
Cytochrome c Group
Female
Gene Rearrangement
Immune Tolerance
Immunization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Major Histocompatibility Complex

Male

Mice

Mice, Inbred Strains

Phenotype

Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 2162903
DOI: 10.1084/jem.172.1.139
PMCID: PMC2188180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2162903-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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