Article
A murine retrovirus induces proliferation of unique lymphoid cell lines expressing T-cell-receptor structures utilizing common variable region alpha and beta chain genes.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
O'Neill H C
Abstract excerpt
A murine radiation leukemia virus (RadLV) has been shown to induce in vitro proliferation of an unusual subset of lymphoid cells from spleen. They have the unusual property of expressing CD3/T-cell receptor alpha and beta chains (TCR-alpha beta) in the absence of other T-cell markers such as Thy-1, CD4, and CD8. Cell lines induced in two mouse strains with RadLV produced by the C6VL/1 thymoma all specifically...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Cell Line
- DNA
- Endocytosis
- Flow Cytometry
- Genetic Variation
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Lymphocyte Subsets