TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.

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Article

TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996

Turner S J, Cose S C, Carbone F R

Abstract excerpt

There is considerable variation in the TCR repertoire diversity selected by different peptide Ags. Certain responses show limited V region bias with minimal restrictions in the remainder of the sequence while others can be dominated by a single TCR clonotype repeatedly isolated from different ind...

Topics

Amino Acid Sequence
Animals
Antigens, Viral
Base Sequence
DNA Primers
Genetic Variation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Molecular Sequence Data
Receptors, Antigen, T-Cell, alpha-beta
Simplexvirus
T-Lymphocytes
Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 8943404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8943404-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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