Article
TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996
Turner S J, Cose S C, Carbone F R
Abstract excerpt
There is considerable variation in the TCR repertoire diversity selected by different peptide Ags. Certain responses show limited V region bias with minimal restrictions in the remainder of the sequence while others can be dominated by a single TCR clonotype repeatedly isolated from different individuals. CTL specific for a Kb-restricted determinant from the herpes simplex virus glycoprotein B (gB) preferentially...
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