Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.

doi:10.4049/jimmunol.152.4.1609

Article

Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.

1 Feb 1994

Abstract excerpt

To assess the influence of graft vs host disease (GVHD) on T cell development and thymic repertoire selection, a murine transplantation model was chosen, in which donor (B10.BR: Mls-1b, Mls-2b) and recipient (CBA/J: Mls-1a, Mls-2a) mice differ in their minor lymphocyte-stimulating Ag. Mature splenic T cells of donor origin were added to the T cell-depleted bone marrow cells to induce moderate GVHD. When analyzed...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.