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Article

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias.

Journal of virology - 1 Sept 1995

Cose S C, Kelly J M, Carbone F R

Abstract excerpt

The glycoprotein B (gB) from herpes simplex virus type I is a major target of cytotoxic T lymphocytes (CTL) in C57BL/6 mice. The majority of these T cells are directed to a single Kb-restricted determinant, gB498-505. We have analyzed the T-cell receptor (TCR) usage in gB-specific CTL lines derived shortly after virus infection. The CTL populations preferentially used two V beta regions, a dominant V beta 10...

Topics

Amino Acid Sequence
Animals
Epitopes
Genetic Variation
Herpesvirus 1, Human
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Polymerase Chain Reaction
Receptors, Antigen, T-Cell, alpha-beta
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Cytotoxic

Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7543591
DOI: 10.1128/JVI.69.9.5849-5852.1995
PMCID: PMC189458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7543591-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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