Article
The inheritance of glomerulosclerosis in mice is controlled by multiple quantitative trait loci.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 1998
Lenz O, Zheng F, Vilar J, Doublier S, Lupia E, Schwedler S, Striker L J, Striker G E
Abstract excerpt
BACKGROUND: Glomerulosclerosis, the common terminal event in chronic glomerular diseases such as diabetic nephropathy or IgA nephropathy, leads to end-stage renal disease. The considerable variation in both the risk of developing glomerulosclerosis and the rate of progression in individual patien...
Topics
- Animals
- Chromosome Mapping
- Female
- Genes, Recessive
- Genetic Predisposition to Disease
- Glomerulosclerosis, Focal Segmental
- Hybridization, Genetic
- Kidney Glomerulus
- Male
- Mice
- Mice, Inbred C3H
- Mice, Mutant Strains
- Quantitative Trait, Heritable