Article
Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors.
The Journal of clinical investigation - 1 Dec 2001
Cornacchia F, Fornoni A, Plati A R, Thomas A, Wang Y, Inverardi L, Striker L J, Striker G E
Abstract excerpt
We found that ROP Os/+ (Os/+) mice had diffuse glomerulosclerosis and glomerular hypertrophy and that their mesangial cells (the vascular smooth muscle cells of the glomerulus) displayed an apparent sclerosing phenotype. Since mesangial cells are the major source of scar tissue in glomerulosclerosis, we postulated that the sclerosis phenotype was carried by mesangial cell progenitors and that this phenotype could...
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