Article
Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2010
Wang Youli, Heilig Kathleen O, Minto Andrew W, Chen Shenglin, Xiang Minghui, Dean David A, Geiger Richard C, Chang Anthony, Pravtcheva Dimitrina D, Schlimme Martin, Deb Dilip K, Wang Ying, Heilig Charles W
Abstract excerpt
Reduced nephron numbers may predispose to renal failure. We hypothesized that glucose transporters (GLUTs) may contribute to progression of the renal disease, as GLUTs have been implicated in diabetic glomerulosclerosis and hypertensive renal disease with mesangial cell (MC) stretch. The Os (oligosyndactyly) allele that typically reduces nephron number by approximately 50%, was repeatedly backcrossed from ROP...
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