Characterization of hemoglobin variants by MALDI-TOF MS using a polyurethane membrane as the sample support.

doi:10.1021/ac9805753

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Article

Characterization of hemoglobin variants by MALDI-TOF MS using a polyurethane membrane as the sample support.

Analytical chemistry - 15 Dec 1998

McComb M E, Oleschuk R D, Chow A, Ens W, Standing K G, Perreault H, Smith M

Abstract excerpt

A new method for the sampling and off-site analysis of hemoglobin variants by mass spectrometry is reported. This technique uses a nonporous polyurethane membrane as the collection device and transportation medium of a blood sample for analysis. The same membrane is then used as the MALDI-TOF MS...

Topics

Genetic Variation
Hemoglobins
Hemoglobins, Abnormal
Humans
Membranes, Artificial
Polyurethanes
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Trypsin

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