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Article

Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus.

American journal of human genetics - 1 Nov 1998

Nielsen D M, Ehm M G, Weir B S

Abstract excerpt

We review and extend a recent suggestion that fine-scale localization of a disease-susceptibility locus for a complex disease be done on the basis of deviations from Hardy-Weinberg equilibrium among affected individuals. This deviation is driven by linkage disequilibrium between disease and marker loci in the whole population and requires a heterogeneous genetic basis for the disease. A finding of marker-locus...

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Identifiers

PMID: 9867708
DOI: 10.1086/302114
PMCID: PMC1377570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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