Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus.

doi:10.1086/302114

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Article

Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus.

American journal of human genetics - 1 Nov 1998

Nielsen D M, Ehm M G, Weir B S

Abstract excerpt

We review and extend a recent suggestion that fine-scale localization of a disease-susceptibility locus for a complex disease be done on the basis of deviations from Hardy-Weinberg equilibrium among affected individuals. This deviation is driven by linkage disequilibrium between disease and marke...

Topics

Alleles
Genes, Recessive
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Heterozygote
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical

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