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Article

QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations.

American journal of human genetics - 1 Mar 2000

Deng H W, Chen W M, Recker R R

Abstract excerpt

It has recently been demonstrated that fine-scale mapping of a susceptibility locus for a complex disease can be accomplished on the basis of deviations from Hardy-Weinberg (HW) equilibrium at closely linked marker loci among affected individuals. We extend this theory to fine-scale localization of a quantitative-trait locus (QTL) from extreme individuals in populations, by means of HW and linkage-disequilibrium...

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Identifiers

PMID: 10712216
DOI: 10.1086/302804
PMCID: PMC1288140

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