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Article

HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998

Burlingham W J, Jankowska-Gan E, DeVito-Haynes L, Fechner J H, Hogan K T, Claas F H, Mulder A, Wang X, Ferrone S

Abstract excerpt

Soluble MHC Ags and anti-Id (anti-anti-MHC) Abs have both been shown to inhibit MHC alloantigen-specific B cell responses in vivo. We hypothesized that some anti-idiotypic Abs function as divalent molecular mimics of soluble HLA alloantigen. To test this idea, we studied two well-defined anti-idiotypic mAbs, T10-505 and T10-938, elicited in syngeneic BALB/c mice by immunization with CRll-351, an...

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PMID: 9862700

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