HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies.

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Article

HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998

Burlingham W J, Jankowska-Gan E, DeVito-Haynes L, Fechner J H, Hogan K T, Claas F H, Mulder A, Wang X, Ferrone S

Abstract excerpt

Soluble MHC Ags and anti-Id (anti-anti-MHC) Abs have both been shown to inhibit MHC alloantigen-specific B cell responses in vivo. We hypothesized that some anti-idiotypic Abs function as divalent molecular mimics of soluble HLA alloantigen. To test this idea, we studied two well-defined anti-idi...

Topics

Alleles
Amino Acid Sequence
Animals
Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Antigen-Antibody Reactions
Cell Line
Cross Reactions
Epitopes
HLA-A2 Antigen
Humans
Hybridomas
Immune Tolerance
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains
Isoantibodies
Male
Mice

Source

Open in PubMed

Identifiers

PMID: 9862700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9862700-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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