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Article

Chromosome 7 rearrangements in glioblastomas; loci adjacent to EGFR are independently amplified.

Journal of neuropathology and experimental neurology - 1 Dec 1998

Liu L, Ichimura K, Pettersson E H, Collins V P

Abstract excerpt

The first gene found to be amplified in human glioblastomas was EGFR at 7p12. More recently the MET gene at 7q31 was also reported amplified. We have studied chromosome 7 in a series of 47 glioblastomas by FISH, RFLP and microsatellite analysis. Four per cent (2/47) had 1 centromere, 26% (12/47)...

Topics

Alleles
Centromere
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 8
Gene Rearrangement
Genes, erbB-1
Glioblastoma
Humans
In Situ Hybridization, Fluorescence
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 9862636
DOI: 10.1097/00005072-199812000-00005

Genes

EGFR
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9862636-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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