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Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer

1 Jan 2009

Abstract excerpt

BACKGROUND: Increase of EGFR gene copy number consequent to gene amplification and/or polysomy of chromosome 7 has been significantly associated with better clinical outcome in Non Small Cell Lung Cancer (NSCLC) patients treated with Tyrosin-Kinase Inhibitors (TKIs).The primary method to detect EGFR copy number is FISH (Fluorescence in Situ Hybridization), that in lung cancer requires a precise standardization...

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PMID: 19889201
DOI: 10.1186/1746-1596-4-36

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