Article
Genetic alterations in a papillary glioneuronal tumor.
Journal of neurosurgery. Pediatrics - 1 Jan 2008
Faria Claudia, Miguéns José, Antunes João Lobo, Barroso Cândida, Pimentel José, Martins Maria Do Carmo, Moura-Nunes Vasco, Roque Lúcia
Abstract excerpt
Papillary glioneuronal tumors (PGNTs) are rare lesions of the central nervous system, and no information exists on the genetic alterations in these neoplasms. The authors report on such a case in a child. Genetic studies revealed that the tumor was characterized by gains and structural alterations involving only chromosome 7 with breakpoints at 7p22. By using comparative genomic hybridization, the authors...
Topics
- Brain Neoplasms
- Child
- Chromosome Breakage
- Chromosomes, Human, Pair 7
- Female
- Ganglioglioma
- Genes, erbB-1
- Genotype
- Glial Fibrillary Acidic Protein
- Glycoproteins
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence