Article
Detailed characterization of alterations of chromosomes 7, 9, and 10 in glioblastomas as assessed by single-nucleotide polymorphism arrays.
The Journal of molecular diagnostics : JMD - 1 Nov 2011
Crespo Inês, Vital Ana Luísa, Nieto Ana Belen, Rebelo Olinda, Tão Hermínio, Lopes Maria Celeste, Oliveira Catarina Resende, French Pim J, Orfao Alberto, Tabernero María Dolores
Abstract excerpt
Glioblastomas are cytogenetically heterogeneous tumors that frequently display alterations of chromosomes 7, 9p, and 10q. We used high-density (500K) single-nucleotide polymorphism arrays to investigate genome-wide copy number alterations and loss of heterozygosity in 35 primary glioblastomas. We focused on the identification and detailed characterization of alterations involving the most frequently altered...
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