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Article

Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors.

Cancer - 15 Sept 2008

Freeman Serena S, Allen Steven W, Ganti Ramapriya, Wu Jianrong, Ma Jing, Su Xiaoping, Neale Geoff, Dome Jeffrey S, Daw Najat C, Khoury Joseph D

Abstract excerpt

BACKGROUND: Osteosarcoma cell lines and tumors have been shown to express epidermal growth factor receptor (EGFR) and harbor amplifications at the EGFR locus. In this study, the authors further analyzed the genomic features of EGFR in osteosarcoma tumors and investigated whether they correlate with phosphatase and tensin homolog (PTEN) expression and copy number status. METHODS: EGFR and PTEN expression was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18704985
DOI: 10.1002/cncr.23782
PMCID: PMC3529469

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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