Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.

Oncogene - 1 Oct 1990

Testa J R, Park M, Blair D G, Kalbakji A, Arden K, Vande Woude G F

Abstract excerpt

We have previously shown that two alleles of the MET locus are independently rearranged in the chemically-treated human cell line MNNG-HOS. One allele is the TPR-MET oncogene which was activated by fusion of the MET locus on chromosome 7 with the TPR locus on chromosome 1. The second allele is found on a der(7)t(1;7)(q23;q32) chromosome and is characterized by a deletion of the amino-terminus of the MET...

Topics

Alleles
Animals
Blotting, Southern
Cell Line
Chromosomes, Human, Pair 7
DNA, Neoplasm
Electrophoresis, Agar Gel
Gene Rearrangement
Genomic Library
Humans
Hybrid Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylnitronitrosoguanidine

Mice

Osteosarcoma

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-met

Proto-Oncogenes

Source

Open in PubMed

Identifiers

PMID: 2250912

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2250912-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.PMID 2250912Read ↗

Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases.Semantic proximity Read ↗

Chromosome 7 rearrangements in glioblastomas; loci adjacent to EGFR are independently amplified.Semantic proximity Read ↗

Physical mapping of a tandem duplication on the long arm of chromosome 7 associated with a multidrug resistant phenotype.Semantic proximity Read ↗

Delineation of multiple deleted regions in 7q in myeloid disordersSemantic proximity Read ↗

Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505).Semantic proximity Read ↗

Mutational analysis of the ST7 gene in human myeloid tumor cell lines.Semantic proximity Read ↗

Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10).Semantic proximity Read ↗

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.Semantic proximity Read ↗

Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.