Article
Frequency and clinical significance of chromosome 7 and 10 aneuploidies, amplification of the EGFR gene, deletion of PTEN and TP53 genes, and 1p/19q deficiency in a sample of adult patients diagnosed with glioblastoma from Southern Brazil.
Journal of neuro-oncology - 1 Dec 2017
Koshiyama Dayane B, Trevisan Patrícia, Graziadio Carla, Rosa Rafael F M, Cunegatto Bibiana, Scholl Juliete, Provenzi Valentina O, de Sá Alexandre P, Soares Fabiano P, Velho Maíra C, de A P Filho Nelson, Oliveira Ceres A, Zen Paulo R G
Abstract excerpt
Glioblastoma stands out as the most frequent central nervous system neoplasia, presenting a poor prognosis. The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnosed with glioblastoma. The sample consisted of 40 patients treated from November 2011 to March...
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