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Article

The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2004

Heux Stephanie, Morin Fabien, Lea Rod A, Ovcaric Micky, Tajouri Lofti, Griffiths Lyn R

Abstract excerpt

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is functionally important, being strongly associated with reduced enzyme activity and increased plasma levels of homocysteine. Mild hyperhomocysteinemia is a known risk factor for cardiovascular disease (CVD) and...

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Identifiers

PMID: 15750260
DOI: 10.1291/hypres.27.663

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians.PMID 15750260Read ↗

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