Article
Methylenetetrahydrofolate reductase 677 C/T genotype and cardiovascular disease mortality in postmenopausal women.
American journal of epidemiology - 1 Apr 2001
Roest M, van der Schouw Y T, Grobbee D E, Tempelman M J, de Groot P G, Sixma J J, Banga J D
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is involved in the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. A 677 C/T single nucleotide polymorphism localized in the MTHFR gene is associated with both thermolability and reduced activity of the enzyme and is associated with increased homocysteine levels. The authors investigated the relation between the MTHFR 677 C/T polymorphism and...
Topics
- Age Distribution
- Aged
- Base Sequence
- Cardiovascular Diseases
- Case-Control Studies
- Cause of Death
- Cohort Studies
- Confidence Intervals
- Female
- Genetic Predisposition to Disease