Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

22 Dec 1998

Abstract excerpt

Tuberous sclerosis is an autosomal dominant disorder characterized by the development of aberrant growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The tuberous sclerosis complex gene-2 (TSC2) on chromosome 16 encodes the tumor suppressor protein tuberin. We have shown earlier that loss of TSC2 is sufficient to induce quiescent cells to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histiocytic Disorders and Treatments
Share to Tuberous Sclerosis Complex Research
Share to Vascular Tumors and Angiosarcomas

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9861025
DOI: 10.1073/pnas.95.26.15653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2PMID 9861025Read ↗

Role of the Tuberous Sclerosis Gene-2 Product in Cell Cycle ControlSemantic proximity Read ↗

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.Semantic proximity Read ↗

The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.Semantic proximity Read ↗

Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1Semantic proximity Read ↗

Cells derived from tuberous sclerosis show a prolonged S phase of the cell cycle and increased apoptosis.Semantic proximity Read ↗

Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expressionSemantic proximity Read ↗

The molecular genetics of tuberous sclerosis.Semantic proximity Read ↗

The tuberous sclerosis complex genes in tumor development.Semantic proximity Read ↗

Non-Canonical Functions of a Mutant TSC2 Protein in Mitotic DivisionSemantic proximity Read ↗

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.Semantic proximity Read ↗

A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.Semantic proximity Read ↗

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.