Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the Tuberous Sclerosis Gene-2 Product in Cell Cycle Control

1 Nov 1997

Abstract excerpt

Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The TSC2 gene on chromosome 16 encodes a 1784-amino acid tumor suppressor protein, tuberin, that functions as a GTPase-activating protein for Rap1, a member of the superfamily of Ras-related...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurofibromatosis and Schwannoma Cases
Share to Tuberous Sclerosis Complex Research
Share to Vascular Tumors and Angiosarcomas

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9361010
DOI: 10.1074/jbc.272.46.29301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the Tuberous Sclerosis Gene-2 Product in Cell Cycle ControlPMID 9361010Read ↗

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2Semantic proximity Read ↗

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.Semantic proximity Read ↗

The molecular genetics of tuberous sclerosis.Semantic proximity Read ↗

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITYSemantic proximity Read ↗

Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1Semantic proximity Read ↗

The TSC1 gene product, hamartin, negatively regulates cell proliferationSemantic proximity Read ↗

A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.Semantic proximity Read ↗

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle.Semantic proximity Read ↗

Cells derived from tuberous sclerosis show a prolonged S phase of the cell cycle and increased apoptosis.Semantic proximity Read ↗

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.Semantic proximity Read ↗

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.Semantic proximity Read ↗

Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.