Article
Cells derived from tuberous sclerosis show a prolonged S phase of the cell cycle and increased apoptosis.
Archives of dermatological research - 1 Sept 2001
Wataya-Kaneda M, Kaneda Y, Hino O, Adachi H, Hirayama Y, Seyama K, Satou T, Yoshikawa K
Abstract excerpt
Tuberous sclerosis complex (TSC) is a multisystemic disorder characterized by systemic hamartomas. Although the disease-determining genes TSC1 and TSC2 have been isolated, the molecular pathogenesis of the disease is not understood. We examined cell cycle abnormalities in skin specimens and cultured cells derived from specific lesions of TSC patients with confirmed TSC1 or TSC2 mutations. None of the specimens...
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