Article
A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
Genetics - 1 Jun 2006
Nakase Yukiko, Fukuda Keiko, Chikashige Yuji, Tsutsumi Chihiro, Morita Daisuke, Kawamoto Shinpei, Ohnuki Mari, Hiraoka Yasushi, Matsumoto Tomohiro
Abstract excerpt
Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GTPase-activating protein (GAP) for Rheb, a GTPase regulating a downstream kinase, mTOR. The genome of Schizosaccharomyces pombe contains tsc1(+) and tsc2(+), homologs of human Tsc1 and Tsc2, respectively. In...
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