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Article

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

Cell - 4 May 2001

Tapon N, Ito N, Dickson B J, Treisman J E, Hariharan I K

Abstract excerpt

The inherited human disease tuberous sclerosis, characterized by hamartomatous tumors, results from mutations in either TSC1 or TSC2. We have characterized mutations in the Drosophila Tsc1 and Tsc2/gigas genes. Inactivating mutations in either gene cause an identical phenotype characterized by enhanced growth and increased cell size with no change in ploidy. Overall, mutant cells spend less time in G1....

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Source

Identifiers

PMID: 11348591
DOI: 10.1016/s0092-8674(01)00332-4

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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