Article

Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1

2021-10-25

Abstract excerpt

Tuberin is a major component of the protein regulatory complex known as the Tuberous Sclerosis Complex and plays a crucial role in cell cycle progression and protein synthesis. Mutations in the Tuberin gene, TSC2 , lead to the formation of benign tumors in many organ systems and causes the Tuberous Sclerosis Complex disorder. Genotypes ranging from point mutations to large deletions in the TSC2 gene have been cl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4562bb4-0128-5fc1-b679-062a01ab0a76
DOI: 10.1101/2021.10.25.465800

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1DOI 10.1101/2021.10.25.465800Read

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITYSemantic proximity Read

The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.Semantic proximity Read

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatmentSemantic proximity Read

Genetics and Molecular Biology of Tuberous Sclerosis ComplexSemantic proximity Read

Molecular genetic basis of tuberous sclerosis complex: from bench to bedside.Semantic proximity Read

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2Semantic proximity Read

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.Semantic proximity Read

The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis.Semantic proximity Read

New insights into tuberous sclerosis complex: from structure to pathogenesisSemantic proximity Read

The molecular genetics of tuberous sclerosis.Semantic proximity Read

The dual role of the TSC complex in cancer.Semantic proximity Read

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis PathogenesisSemantic proximity Read