Article

Non-Canonical Functions of a Mutant TSC2 Protein in Mitotic Division

2022-12-07

Abstract excerpt

<h4>SUMMARY</h4> Tuberous Sclerosis Complex (TSC) is a debilitating neurodevelopmental disorder characterized by a variety of clinical manifestations including epilepsy, autism, and intellectual disability. TSC is caused by mutations in the TSC1 or TSC2 genes, which encode the hamartin/tuberin proteins respectively. These proteins function as a heterodimer that negatively regulates mechanistic Target of Rapamyc...

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Literature Corpus work: ba11e01d-beee-55b4-ba9f-d7e6a05e988c
DOI: 10.1101/2022.12.07.519401

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