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Article

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.

Oncogene - 11 Aug 2011

Jäkel H, Weinl C, Hengst L

Abstract excerpt

Janus kinase 2 (JAK2) couples ligand activation of cell surface cytokine receptors to the regulation of cellular functions including cell cycle progression, differentiation and apoptosis. It thereby coordinates biological programs such as development and hematopoiesis. Unscheduled activation of JAK2 by point mutations or chromosomal translocations can induce hyperproliferation and hematological malignancies....

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Source

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Identifiers

PMID: 21423214
DOI: 10.1038/onc.2011.68
PMCID: PMC3160490

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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