Article
A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Ginns E I, St Jean P, Philibert R A, Galdzicka M, Damschroder-Williams P, Thiel B, Long R T, Ingraham L J, Dalwaldi H, Murray M A, Ehlert M, Paul S, Remortel B G, Patel A P, Anderson M C, Shaio C, Lau E, Dymarskaia I, Martin B M, Stubblefield B, Falls K M, Carulli J P, Keith T P, Fann C S, Lacy L G, Allen C R, Hostetter A M, Elston R C, Schork N J, Egeland J A, Paul S M
Abstract excerpt
Bipolar affective disorder (BPAD; manic-depressive illness) is characterized by episodes of mania and/or hypomania interspersed with periods of depression. Compelling evidence supports a significant genetic component in the susceptibility to develop BPAD. To date, however, linkage studies have attempted only to identify chromosomal loci that cause or increase the risk of developing BPAD. To determine whether...
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