Article
Genome screen of 15 Australian bipolar affective disorder pedigrees supports previously identified loci for bipolar susceptibility genes.
Psychiatric genetics - 1 Aug 2008
Fullerton Janice M, Liu Zhixin, Badenhop Renee F, Scimone Anna, Blair Ian P, Van Herten Mary, Donald Jennifer A, Mitchell Philip B, Schofield Peter R
Abstract excerpt
OBJECTIVE: Despite many studies into the genetics of bipolar disorder (BP), the molecular causes underlying susceptibility to BP remain unclear. The aim of this study was to identify chromosomal regions linked to BP in a new Australian extended pedigree cohort. METHODS: We have conducted a parametric genome-wide linkage scan on 15 previously unreported Australian extended families with BP and related affective...
Topics
- Australia
- Bipolar Disorder
- Chromosomes, Human
- Cohort Studies
- Computer Simulation
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genome, Human
- Humans
- Lod Score
- Male
- Pedigree