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Article

Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.

BMC genetics - 15 Mar 2015

Kember Rachel L, Georgi Benjamin, Bailey-Wilson Joan E, Stambolian Dwight, Paul Steven M, Bućan Maja

Abstract excerpt

BACKGROUND: Bipolar affective disorder (BP) is a common, highly heritable psychiatric disorder characterized by periods of depression and mania. Using dense SNP genotype data, we characterized CNVs in 388 members of an Old Order Amish Pedigree with bipolar disorder. We identified CNV regions arising from common ancestral mutations by utilizing the pedigree information. By combining this analysis with whole genome...

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Identifiers

PMID: 25887117
DOI: 10.1186/s12863-015-0184-1
PMCID: PMC4382929

Genes

BPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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