Article
Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees.
American journal of medical genetics - 7 Feb 2000
Foroud T, Castelluccio P F, Koller D L, Edenberg H J, Miller M, Bowman E, Rau N L, Smiley C, Rice J P, Goate A, Armstrong C, Bierut L J, Reich T, Detera-Wadleigh S D, Goldin L R, Badner J A, Guroff J J, Gershon E S, McMahon F J, Simpson S, MacKinnon D, McInnis M, Stine O C, DePaulo J R, Blehar M C, Nurnberger J I
Abstract excerpt
As part of a four-center NIMH Genetics Initiative on Bipolar Disorder, a genome screen using 365 markers was performed on 540 DNAs from 97 families, enriched for affected relative pairs. This is the largest uniformly ascertained and assessed linkage sample for this disease, and includes 232 subjects diagnosed with bipolar I (BPI), 32 with schizo-affective, bipolar type (SABP), 72 with bipolar II (BPII), and 88...
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