Article
Update on the search for DNA markers linked to manic-depressive illness in the Old Order Amish.
Journal of psychiatric research - 1 Oct 1992
Ginns E I, Egeland J A, Allen C R, Pauls D L, Falls K, Keith T P, Paul S M
Abstract excerpt
In this report we describe our efforts to identify a gene involved in bipolar illness using a large, multigenerational Old Order Amish pedigree with many affected individuals. The original collection of cell lines from Amish pedigree 110 has been extended to include 169 individuals. We have used over 250 markers spaced at approximately 20 centiMorgans that detect restriction length fragment polymorphisms, but no...
Topics
- Bipolar Disorder
- Cell Line
- Chromosome Mapping
- Ethnicity
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Male
- Models, Genetic
- Phenotype
- Polymorphism, Restriction Fragment Length