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Article

Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents.

Human genetics - 1 Nov 1998

Roth H, Korn T, Rosenkranz K, Hinney A, Ziegler A, Kunz J, Siegfried W, Mayer H, Hebebrand J, Grzeschik K H

Abstract excerpt

Genetic determinants of the degree of obesity and body fat distribution have been demonstrated by family studies. The heritability has been estimated to be in the range 0.2-0.7. Mutation leading to obesity in humans has been described for only two genes, one of them the leptin gene. The leptin gene codes for a cytokine secreted by fat cells that binds to the leptin receptor (Lep-R), which exerts some of its...

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PMID: 9860295
DOI: 10.1007/s004390050867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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