Article
Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents.
Human genetics - 1 Nov 1998
Roth H, Korn T, Rosenkranz K, Hinney A, Ziegler A, Kunz J, Siegfried W, Mayer H, Hebebrand J, Grzeschik K H
Abstract excerpt
Genetic determinants of the degree of obesity and body fat distribution have been demonstrated by family studies. The heritability has been estimated to be in the range 0.2-0.7. Mutation leading to obesity in humans has been described for only two genes, one of them the leptin gene. The leptin ge...
Topics
- Adolescent
- Alleles
- Carrier Proteins
- Chromosome Mapping
- Cloning, Molecular
- DNA Mutational Analysis
- DNA Primers
- Female
- Genotype
- Germany
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Microsatellite Repeats