Article
Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight.
Annals of human genetics - 1 Sept 2000
Mammès O, Betoulle D, Aubert R, Herbeth B, Siest G, Fumeron F
Abstract excerpt
Mutations in the translated part of the leptin gene (LEP) have been found in only two families. Nevertheless DNA polymorphisms in the LEP region are linked to extreme obesity. We previously found in the 5' region of LEP a polymorphism, G-2548A, associated with a differerce in BMI reduction following a low calorie diet in overweight women. Recently, this polymorphism was associated with extreme obesity in women....
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