Article
Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women.
Annals of human genetics - 1 May 1999
Li W D, Reed D R, Lee J H, Xu W, Kilker R L, Sodam B R, Price R A
Abstract excerpt
Few mutations have been found in the human leptin gene and the relationship between leptin gene sequence variation and human overweight is uncertain. To determine whether sequence variation within the leptin gene and its regulatory elements contribute to extreme obesity, we screened approximately 3 kb of the 5' flanking region and the three exons in 125 unrelated extremely obese (BMI > or = 40 kg/m2) and 86...
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