Article
Cyclosporin A promotes translational silencing of autocrine interleukin-3 via ribosome-associated deadenylation.
Molecular and cellular biology - 1 Jan 1999
Nair A P, Hirsch H H, Colombi M, Moroni C
Abstract excerpt
Translation is regulated predominantly by an interplay between cis elements at the 3' and 5' ends of mRNAs and trans-acting proteins. Cyclosporin A (CsA), a calcineurin antagonist and blocker of interleukin-2 (IL-2) transcription in T cells, was found to inhibit translation of IL-3 mRNA in autocr...
Topics
- Animals
- Cell Line
- Cyclosporine
- Down-Regulation
- Humans
- Immunosuppressive Agents
- Interleukin-3
- Intracellular Membranes
- Jurkat Cells
- Mice
- Mice, Inbred DBA
- Phenotype
- Poly A
- Polyribosomes
- Protein Biosynthesis
- RNA, Messenger
- RNA, Ribosomal
- Ribosomes