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Article

Cyclosporin A promotes translational silencing of autocrine interleukin-3 via ribosome-associated deadenylation.

Molecular and cellular biology - 1 Jan 1999

Nair A P, Hirsch H H, Colombi M, Moroni C

Abstract excerpt

Translation is regulated predominantly by an interplay between cis elements at the 3' and 5' ends of mRNAs and trans-acting proteins. Cyclosporin A (CsA), a calcineurin antagonist and blocker of interleukin-2 (IL-2) transcription in T cells, was found to inhibit translation of IL-3 mRNA in autocrine mast cell tumor lines. The mechanism involved ribosome-associated poly(A) shortening and required an intact AU-rich...

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Identifiers

PMID: 9858612
DOI: 10.1128/MCB.19.1.889
PMCID: PMC83946

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Source receipt: pubmed, retrieved 7 Sept 2026.

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